| FC Liverpool | - | AC Fiorentina | 1:2 | 9. 12. 2009 |
| Olympique Lyon | - | Debrecín VSC | 4:0 | 9. 12. 2009 |
| Inter Milán | - | FC Rubin Kazaň | 2:0 | 9. 12. 2009 |
| Dynamo Kyjev | - | FC Barcelona | 1:2 | 9. 12. 2009 |
| VfB Stuttgart | - | FC Unirea Urziceni | 3:1 | 9. 12. 2009 |
| Sevilla FC | - | Glasgow Rangers FC | 1:0 | 9. 12. 2009 |
| Olympiakos Pireus | - | Arsenal Londýn | 1:0 | 9. 12. 2009 |
| Standard Lutych | - | AZ Alkmaar | 1:1 | 9. 12. 2009 |
| Besiktas | - | CSKA Moskva | 1:2 | 8. 12. 2009 |
| VfL Wolfsburg | - | Manchester United | 1:3 | 8. 12. 2009 |
| Juventus Turín | - | Bayern Mnichov | 1:4 | 8. 12. 2009 |
| Maccabi Haifa FC | - | Girondins Bordeaux | 0:1 | 8. 12. 2009 |
| FC Zurich | - | AC Milán | 1:1 | 8. 12. 2009 |
| Olympique Marseille | - | Real Madrid C.F. | 1:3 | 8. 12. 2009 |
| Chelsea FC | - | APOEL FC | 2:2 | 8. 12. 2009 |
| Atlético Madrid | - | FC Porto | 0:3 | 8. 12. 2009 |
tabulky:
| Skupina A | |||||||
| 1 | Bordeaux | 6 | 5 | 1 | 0 | 9:2 | 16 |
| 2 | Bayern | 6 | 3 | 1 | 2 | 9:5 | 10 |
| 3 | Juventus | 6 | 2 | 2 | 2 | 4:7 | 8 |
| 4 | Maccabi Haifa | 6 | 0 | 0 | 6 | 0:8 | 0 |
| Skupina B | |||||||
| 1 | Manchester Utd. | 6 | 4 | 1 | 1 | 10:6 | 13 |
| 2 | CSKA | 6 | 3 | 1 | 2 | 10:10 | 10 |
| 3 | Wolfsburg | 6 | 2 | 1 | 3 | 9:8 | 7 |
| 4 | Besiktas | 6 | 1 | 1 | 4 | 3:8 | 4 |
| Skupina C | |||||||
| 1 | Real Madrid | 6 | 4 | 1 | 1 | 15:7 | 13 |
| 2 | AC Milán | 6 | 2 | 3 | 1 | 8:7 | 9 |
| 3 | Marseille | 6 | 2 | 1 | 3 | 10:10 | 7 |
| 4 | Zurich | 6 | 1 | 1 | 4 | 5:14 | 4 |
| Skupina D | |||||||
| 1 | Chelsea | 6 | 4 | 2 | 0 | 11:4 | 14 |
| 2 | Porto | 6 | 4 | 0 | 2 | 9:3 | 12 |
| 3 | APOEL | 6 | 0 | 3 | 3 | 4:8 | 3 |
| 4 | Atlético | 6 | 0 | 3 | 3 | 3:12 | 3 |
| Skupina E | |||||||
| 1 | Fiorentina | 6 | 5 | 0 | 1 | 14:7 | 15 |
| 2 | Lyon | 6 | 4 | 1 | 1 | 12:3 | 13 |
| 3 | Liverpool | 6 | 2 | 1 | 3 | 5:7 | 7 |
| 4 | Debrecín | 6 | 0 | 0 | 6 | 5:19 | 0 |
| Skupina F | |||||||
| 1 | Barcelona | 6 | 3 | 2 | 1 | 7:3 | 11 |
| 2 | Inter | 6 | 2 | 3 | 1 | 7:6 | 9 |
| 3 | Kazaň | 6 | 1 | 3 | 2 | 4:7 | 6 |
| 4 | Kyjev | 6 | 1 | 2 | 3 | 7:9 | 5 |
| Skupina G | |||||||
| 1 | Sevilla | 6 | 4 | 1 | 1 | 11:4 | 13 |
| 2 | Stuttgart | 6 | 2 | 3 | 1 | 9:7 | 9 |
| 3 | Urziceni | 6 | 2 | 2 | 2 | 8:8 | 8 |
| 4 | Rangers | 6 | 0 | 2 | 4 | 4:13 | 2 |
Skupina H | |||||||
| 1 | Arsenal | 6 | 4 | 1 | 1 | 12:5 | 13 |
| 2 | Olympiakos | 6 | 3 | 1 | 2 | 4:5 | 10 |
| 3 | Standard | 6 | 1 | 2 | 3 | 7:9 | 5 |
| 4 | Alkmaar | 6 | 0 | 4 | 2 | 4:8 | 4 |
postupují: Bordeaux ( Jaroslav Plašil) , Bayern Mnichov, Manchester United, CSKA Moskva ( Tomáš Necid) , Real Madrid, AC Milán ( Marek Jankulovski) , Chelsea ( Petr Čech) , Porto, Fiorentina, Lyon, Barcelona, Inter Milán, Sevilla, Stuttgart, Arsenal ( Tomáš Rosický) , Olympiakos