Chelsea - West Bromwich Albion 6:0
Newcastle United - Manchester United 0:3
Liverpool - Arsenal 1:1
Tottenham - Manchester City 0:0
Wigan - Blackpool 0:4
Blackburn - Everton 0:1
Wolverhampton - Stoke City 2:1
Sunderland - Birmingham 2:2
Bolton - Fulham 0:0
Aston Villa - West Ham United 3:0
V prvním kole Premier League padlo celkově 26 gólů, což je průměrně na zápas 2,6 branek.
tabulka po 1. kole:
| Por. | Tým | Z | V | R | P | Skóre | B |
|---|---|---|---|---|---|---|---|
| 1 | Chelsea | 1 | 1 | 0 | 0 | 6:0 | 3 |
| 2 | Blackpool | 1 | 1 | 0 | 0 | 4:0 | 3 |
| 3 | Manchester Utd. | 1 | 1 | 0 | 0 | 3:0 | 3 |
| 4 | Aston Villa | 1 | 1 | 0 | 0 | 3:0 | 3 |
| 5 | Wolves | 1 | 1 | 0 | 0 | 2:1 | 3 |
| 6 | Blackburn | 1 | 1 | 0 | 0 | 1:0 | 3 |
| 7 | Birm'ham | 1 | 0 | 1 | 0 | 2:2 | 1 |
| 8 | Sunderland | 1 | 0 | 1 | 0 | 2:2 | 1 |
| 9 | Arsenal | 1 | 0 | 1 | 0 | 1:1 | 1 |
| 10 | Liverpool | 1 | 0 | 1 | 0 | 1:1 | 1 |
| 11 | Bolton | 1 | 0 | 1 | 0 | 0:0 | 1 |
| 12 | Fulham | 1 | 0 | 1 | 0 | 0:0 | 1 |
| 13 | Manchester City | 1 | 0 | 1 | 0 | 0:0 | 1 |
| 14 | Tottenham | 1 | 0 | 1 | 0 | 0:0 | 1 |
| 15 | Stoke | 1 | 0 | 0 | 1 | 1:2 | 0 |
| 16 | Everton | 1 | 0 | 0 | 1 | 0:1 | 0 |
| 17 | Newcastle | 1 | 0 | 0 | 1 | 0:3 | 0 |
| 18 | West Ham | 1 | 0 | 0 | 1 | 0:3 | 0 |
| 19 | Wigan | 1 | 0 | 0 | 1 | 0:4 | 0 |
| 20 | W.B.A. | 1 | 0 | 0 | 1 | 0:6 | 0 |
následující kolo:
| Manchester City FC | - | FC Liverpool | 23. 8. 2010 |
| Fulham FC | - | Manchester United | 22. 8. 2010 |
| Newcastle United FC | - | FC Aston Villa | 22. 8. 2010 |
| Wigan Athletics FC | - | Chelsea FC | 21. 8. 2010 |
| Arsenal Londýn | - | Blackpool FC | 21. 8. 2010 |
| Birmingham City FC | - | Blackburn Rovers FC | 21. 8. 2010 |
| Everton FC | - | Wolverhampton Wanderers | 21. 8. 2010 |
| Stoke City | - | Tottenham Hotspur FC | 21. 8. 2010 |
| West Bromwich Albion | - | Sunderland AFC | 21. 8. 2010 |
| West Ham United | - | Bolton Wanderers FC | 21. 8. 2010 |