výsledky kola:
| Manchester City FC | - | Lech Poznaň | 3:1 | 21. 10. 2010 | |
| FC Red Bull Salcburk | - | Juventus Turín | 1:1 | 21. 10. 2010 | |
| Atlético Madrid | - | Rosenborg Trondheim | 3:0 | 21. 10. 2010 | |
| Aris Soluň | - | Bayer 04 Leverkusen | 0:0 | 21. 10. 2010 | |
| Sporting Lisabon | - | K.A.A. Gent | 5:1 | 21. 10. 2010 | |
| LOSC Lille Metropole | - | PFC Levski Sofia | 1:0 | 21. 10. 2010 | |
| Villarreal CF | - | PAOK Soluň | 1:0 | 21. 10. 2010 | |
| Dinamo Záhřeb | - | FC Bruggy | 0:0 | 21. 10. 2010 | |
| Šeriff Tiraspol | - | BATE Borisov | 0:1 | 21. 10. 2010 | |
| AZ Alkmaar | - | Dynamo Kyjev | 1:2 | 21. 10. 2010 | |
| Palermo | - | CSKA Moskva | 0:3 | 21. 10. 2010 | |
| AC Sparta Praha | - | FC Lausanne-Sport | 3:3 | 21. 10. 2010 | |
| Zenit Petrohrad | - | HNK Hajduk Split | 2:0 | 21. 10. 2010 | |
| Anderlecht Brusel | - | AEK Atény | 3:0 | 21. 10. 2010 | |
| Young Boys Bern | - | Odense BK | 4:2 | 21. 10. 2010 | |
| VfB Stuttgart | - | Getafe CF | 1:0 | 21. 10. 2010 | |
| Metalist Charkov | - | Sampdoria Janov | 2:1 | 21. 10. 2010 | |
| Debrecín VSC | - | PSV Eindhoven | 1:2 | 21. 10. 2010 | |
| Borussia Dortmund | - | Paris Saint-Germain | 1:1 | 21. 10. 2010 | |
| FC Karpaty Lviv | - | Sevilla FC | 0:1 | 21. 10. 2010 | |
| FC Utrecht | - | Steaua Bukurešť | 1:1 | 21. 10. 2010 | |
| SSC Neapol | - | FC Liverpool | 0:0 | 21. 10. 2010 | |
| CSKA Sofie | - | SK Rapid Vídeň | 0:2 | 21. 10. 2010 | |
| Besiktas | - | FC Porto | 1:3 | 21. 10. 2010 |
tabulky skupin:
| Skupina A | |||||||
| 1 | Manchester City | 3 | 2 | 1 | 0 | 6:2 | 7 |
| 2 | Poznaň | 3 | 1 | 1 | 1 | 6:6 | 4 |
| 3 | Juventus | 3 | 0 | 3 | 0 | 5:5 | 3 |
| 4 | Salcburk | 3 | 0 | 1 | 2 | 1:5 | 1 |
Skupina B | |||||||
| 1 | Leverkusen | 3 | 1 | 2 | 0 | 5:1 | 5 |
| 2 | Atlético | 3 | 1 | 1 | 1 | 4:2 | 4 |
| 3 | Aris | 3 | 1 | 1 | 1 | 2:2 | 4 |
| 4 | Rosenborg | 3 | 1 | 0 | 2 | 2:8 | 3 |
Skupina C | |||||||
| 1 | Sporting | 3 | 3 | 0 | 0 | 12:2 | 9 |
| 2 | Lille | 3 | 1 | 1 | 1 | 3:3 | 4 |
| 3 | Levski | 3 | 1 | 0 | 2 | 3:8 | 3 |
| 4 | GENT | 3 | 0 | 1 | 2 | 4:9 | 1 |
Skupina D | |||||||
| 1 | Villarreal | 3 | 2 | 0 | 1 | 3:3 | 6 |
| 2 | Dinamo Záhřeb | 3 | 1 | 1 | 1 | 2:1 | 4 |
| 3 | PAOK Soluň | 3 | 1 | 1 | 1 | 2:2 | 4 |
| 4 | Bruggy | 3 | 0 | 2 | 1 | 2:3 | 2 |
Skupina E | |||||||
| 1 | BATE | 3 | 2 | 1 | 0 | 7:3 | 7 |
| 2 | Kyjev | 3 | 1 | 1 | 1 | 4:5 | 4 |
| 3 | Tiraspol | 3 | 1 | 0 | 2 | 3:3 | 3 |
| 4 | Alkmaar | 3 | 1 | 0 | 2 | 4:7 | 3 |
Skupina F | |||||||
| 1 | CSKA | 3 | 3 | 0 | 0 | 9:0 | 9 |
| 2 | Sparta | 3 | 1 | 1 | 1 | 6:8 | 4 |
| 3 | Palermo | 3 | 1 | 0 | 2 | 3:6 | 3 |
| 4 | Lausanne | 3 | 0 | 1 | 2 | 3:7 | 1 |
Skupina G | |||||||
| 1 | Zenit | 3 | 3 | 0 | 0 | 9:3 | 9 |
| 2 | Anderlecht | 3 | 1 | 0 | 2 | 4:4 | 3 |
| 3 | AEK | 3 | 1 | 0 | 2 | 5:8 | 3 |
| 4 | Hajduk Split | 3 | 1 | 0 | 2 | 2:5 | 3 |
Skupina H | |||||||
| 1 | Stuttgart | 3 | 3 | 0 | 0 | 6:1 | 9 |
| 2 | YB Bern | 3 | 2 | 0 | 1 | 6:5 | 6 |
| 3 | Getafe | 3 | 1 | 0 | 2 | 2:4 | 3 |
| 4 | Odense | 3 | 0 | 0 | 3 | 4:8 | 0 |
Skupina I | |||||||
| 1 | Eindhoven | 3 | 2 | 1 | 0 | 5:2 | 7 |
| 2 | Metalist | 3 | 2 | 0 | 1 | 7:3 | 6 |
| 3 | Sampdoria | 3 | 1 | 1 | 1 | 3:3 | 4 |
| 4 | Debrecín | 3 | 0 | 0 | 3 | 1:8 | 0 |
Skupina J | |||||||
| 1 | PSG | 3 | 2 | 1 | 0 | 4:1 | 7 |
| 2 | Sevilla | 3 | 2 | 0 | 1 | 2:1 | 6 |
| 3 | Dortmund | 3 | 1 | 1 | 1 | 5:5 | 4 |
| 4 | Karpaty | 3 | 0 | 0 | 3 | 3:7 | 0 |
Skupina K | |||||||
| 1 | Liverpool | 3 | 1 | 2 | 0 | 4:1 | 5 |
| 2 | Neapol | 3 | 0 | 3 | 0 | 3:3 | 3 |
| 3 | Utrecht | 3 | 0 | 3 | 0 | 1:1 | 3 |
| 4 | Steaua | 3 | 0 | 2 | 1 | 5:8 | 2 |
Skupina L | |||||||
| 1 | Porto | 3 | 3 | 0 | 0 | 7:1 | 9 |
| 2 | Besiktas | 3 | 2 | 0 | 1 | 4:4 | 6 |
| 3 | Rapid | 3 | 1 | 0 | 2 | 3:5 | 3 |
| 4 | Sofie | 3 | 0 | 0 | 3 | 0:4 | 0 |