Chelsea - Fulham 1:0
Manchester City - Manchester United 0:0
Wolverhampton - Arsenal 0:2
Wigan - Liverpool 1:1
Tottenham - Sunderland 1:1
Aston Villa - Blackpool 3:2
Stoke City - Birmingham 3:2
West Ham United - West Bromwich Albion 2:2
Newcastle United - Blackburn 1:2
Everton - Bolton 1:1
Ve 12. kole Premier League celkem padlo 26 gólů, průměrně na zápas to je 2,6 branek.
tabulka po 12. kole:
| Por. | Tým | Z | V | R | P | Skóre | B |
|---|---|---|---|---|---|---|---|
| 1 | Chelsea | 12 | 9 | 1 | 2 | 28:5 | 28 |
| 2 | Manchester Utd. | 12 | 6 | 6 | 0 | 24:13 | 24 |
| 3 | Arsenal | 12 | 7 | 2 | 3 | 24:11 | 23 |
| 4 | Manchester City | 12 | 6 | 3 | 3 | 15:10 | 21 |
| 5 | Newcastle | 12 | 5 | 2 | 5 | 21:16 | 17 |
| 6 | Bolton | 12 | 3 | 7 | 2 | 18:17 | 16 |
| 7 | Tottenham | 12 | 4 | 4 | 4 | 14:15 | 16 |
| 8 | Sunderland | 12 | 3 | 7 | 2 | 12:13 | 16 |
| 9 | Liverpool | 12 | 4 | 4 | 4 | 13:15 | 16 |
| 10 | Aston Villa | 12 | 4 | 4 | 4 | 13:16 | 16 |
| 11 | West Bromwich | 12 | 4 | 4 | 4 | 16:21 | 16 |
| 12 | Everton | 12 | 3 | 6 | 3 | 13:11 | 15 |
| 13 | Blackburn | 12 | 4 | 3 | 5 | 13:14 | 15 |
| 14 | Blackpool | 12 | 4 | 2 | 6 | 19:26 | 14 |
| 15 | Fulham | 12 | 2 | 7 | 3 | 13:13 | 13 |
| 16 | Stoke | 12 | 4 | 1 | 7 | 13:18 | 13 |
| 17 | Birm'ham | 12 | 2 | 6 | 4 | 14:17 | 12 |
| 18 | Wigan | 12 | 2 | 5 | 5 | 9:21 | 11 |
| 19 | Wolves | 12 | 2 | 3 | 7 | 11:20 | 9 |
| 20 | West Ham | 12 | 1 | 5 | 6 | 11:22 | 8 |
následující kolo:
| Chelsea FC | - | Sunderland AFC | 14. 11. 2010 |
| Everton FC | - | Arsenal F.C. | 14. 11. 2010 |
| Stoke City | - | FC Liverpool | 13. 11. 2010 |
| Manchester City FC | - | Birmingham City FC | 13. 11. 2010 |
| Newcastle United FC | - | Fulham FC | 13. 11. 2010 |
| Tottenham Hotspur FC | - | Blackburn Rovers FC | 13. 11. 2010 |
| West Ham United | - | Blackpool FC | 13. 11. 2010 |
| Wigan Athletics FC | - | West Bromwich Albion | 13. 11. 2010 |
| Wolverhampton Wanderers | - | Bolton Wanderers FC | 13. 11. 2010 |
| FC Aston Villa | - | Manchester United | 13. 11. 2010 |