výsledky:
| FC Basilej | - | AS Řím | 2:3 | 3. 11. 2010 | |
| CFR Kluž | - | Bayern Mnichov | 0:4 | 3. 11. 2010 | |
| Chelsea FC | - | Spartak Moskva | 4:1 | 3. 11. 2010 | |
| MŠK Žilina | - | Olympique Marseille | 0:7 | 3. 11. 2010 | |
| AJ Auxerre | - | Ajax Amsterdam | 2:1 | 3. 11. 2010 | |
| AC Milán | - | Real Madrid C.F. | 2:2 | 3. 11. 2010 | |
| Partizan Bělehrad | - | Sporting Braga | 0:1 | 3. 11. 2010 | |
| FK Šachtar Doněck | - | Arsenal F.C. | 2:1 | 3. 11. 2010 | |
| Hapoel Tel Aviv | - | Schalke 04 | 0:0 | 2. 11. 2010 | |
| Tottenham Hotspur FC | - | Inter Milán | 3:1 | 2. 11. 2010 | |
| SV Werder Brémy | - | Twente Enschede | 0:2 | 2. 11. 2010 | |
| Benfica Lisabon FC | - | Olympique Lyon | 4:3 | 2. 11. 2010 | |
| Valencia CF | - | Glasgow Rangers FC | 3:0 | 2. 11. 2010 | |
| Bursaspor | - | Manchester United | 0:3 | 2. 11. 2010 | |
| FC Kodaň | - | FC Barcelona | 1:1 | 2. 11. 2010 | |
| FC Rubin Kazaň | - | Panathinaikos Atény | 0:0 | 2. 11. 2010 |
tabulky:
| Skupina A | |||||||
| 1 | Tottenham | 4 | 2 | 1 | 1 | 12:8 | 7 |
| 2 | Inter | 4 | 2 | 1 | 1 | 11:8 | 7 |
| 3 | Twente | 4 | 1 | 2 | 1 | 6:7 | 5 |
| 4 | Brémy | 4 | 0 | 2 | 2 | 3:9 | 2 |
Skupina B | |||||||
| 1 | Lyon | 4 | 3 | 0 | 1 | 9:5 | 9 |
| 2 | Schalke | 4 | 2 | 1 | 1 | 5:2 | 7 |
| 3 | Benfica | 4 | 2 | 0 | 2 | 6:7 | 6 |
| 4 | Hapoel | 4 | 0 | 1 | 3 | 2:8 | 1 |
Skupina C | |||||||
| 1 | Manchester Utd. | 4 | 3 | 1 | 0 | 5:0 | 10 |
| 2 | Valencia | 4 | 2 | 1 | 1 | 8:2 | 7 |
| 3 | Rangers | 4 | 1 | 2 | 1 | 2:4 | 5 |
| 4 | Bursaspor | 4 | 0 | 0 | 4 | 0:9 | 0 |
Skupina D | |||||||
| 1 | Barcelona | 4 | 2 | 2 | 0 | 9:3 | 8 |
| 2 | Kodaň | 4 | 2 | 1 | 1 | 4:3 | 7 |
| 3 | Kazaň | 4 | 0 | 3 | 1 | 1:2 | 3 |
| 4 | Panathinaikos | 4 | 0 | 2 | 2 | 1:7 | 2 |
Skupina E | |||||||
| 1 | Bayern | 4 | 4 | 0 | 0 | 11:3 | 12 |
| 2 | AS Řím | 4 | 2 | 0 | 2 | 6:8 | 6 |
| 3 | Basilej | 4 | 1 | 0 | 3 | 7:8 | 3 |
| 4 | Kluž | 4 | 1 | 0 | 3 | 5:10 | 3 |
Skupina F | |||||||
| 1 | Chelsea | 4 | 4 | 0 | 0 | 12:2 | 12 |
| 2 | Marseille | 4 | 2 | 0 | 2 | 8:3 | 6 |
| 3 | Spartak | 4 | 2 | 0 | 2 | 5:6 | 6 |
| 4 | Žilina | 4 | 0 | 0 | 4 | 1:15 | 0 |
Skupina G | |||||||
| 1 | Real Madrid | 4 | 3 | 1 | 0 | 7:2 | 10 |
| 2 | AC Milán | 4 | 1 | 2 | 1 | 5:5 | 5 |
| 3 | Ajax | 4 | 1 | 1 | 2 | 4:6 | 4 |
| 4 | Auxerre | 4 | 1 | 0 | 3 | 3:6 | 3 |
Skupina H | |||||||
| 1 | Arsenal | 4 | 3 | 0 | 1 | 15:4 | 9 |
| 2 | Šachtar | 4 | 3 | 0 | 1 | 7:6 | 9 |
| 3 | Braga | 4 | 2 | 0 | 2 | 3:9 | 6 |
| 4 | Partizan | 4 | 0 | 0 | 4 | 1:7 | 0 |