výsledky:
| HNK Hajduk Split | - | Zenit Petrohrad | 2:3 | 4. 11. 2010 | |
| AEK Atény | - | Anderlecht Brusel | 1:1 | 4. 11. 2010 | |
| Odense BK | - | Young Boys Bern | 2:0 | 4. 11. 2010 | |
| Getafe CF | - | VfB Stuttgart | 0:3 | 4. 11. 2010 | |
| Sampdoria Janov | - | Metalist Charkov | 0:0 | 4. 11. 2010 | |
| PSV Eindhoven | - | Debrecín VSC | 3:0 | 4. 11. 2010 | |
| Paris Saint-Germain | - | Borussia Dortmund | 0:0 | 4. 11. 2010 | |
| Sevilla FC | - | FC Karpaty Lviv | 4:0 | 4. 11. 2010 | |
| Steaua Bukurešť | - | FC Utrecht | 3:1 | 4. 11. 2010 | |
| FC Liverpool | - | SSC Neapol | 3:1 | 4. 11. 2010 | |
| SK Rapid Vídeň | - | CSKA Sofie | 1:2 | 4. 11. 2010 | |
| FC Porto | - | Besiktas | 1:1 | 4. 11. 2010 | |
| Lech Poznaň | - | Manchester City FC | 3:1 | 4. 11. 2010 | |
| Juventus Turín | - | FC Red Bull Salcburk | 0:0 | 4. 11. 2010 | |
| Rosenborg Trondheim | - | Atlético Madrid | 1:2 | 4. 11. 2010 | |
| Bayer 04 Leverkusen | - | Aris Soluň | 1:0 | 4. 11. 2010 | |
| K.A.A. Gent | - | Sporting Lisabon | 3:1 | 4. 11. 2010 | |
| PFC Levski Sofia | - | LOSC Lille Metropole | 2:2 | 4. 11. 2010 | |
| PAOK Soluň | - | Villarreal CF | 1:0 | 4. 11. 2010 | |
| FC Bruggy | - | Dinamo Záhřeb | 0:2 | 4. 11. 2010 | |
| BATE Borisov | - | Šeriff Tiraspol | 3:1 | 4. 11. 2010 | |
| Dynamo Kyjev | - | AZ Alkmaar | 2:0 | 4. 11. 2010 | |
| CSKA Moskva | - | Palermo | 3:1 | 4. 11. 2010 | |
| FC Lausanne-Sport | - | AC Sparta Praha | 1:3 | 4. 11. 2010 |
tabulky:
| Skupina A | |||||||
| 1 | Poznaň | 4 | 2 | 1 | 1 | 9:7 | 7 |
| 2 | Manchester City | 4 | 2 | 1 | 1 | 7:5 | 7 |
| 3 | Juventus | 4 | 0 | 4 | 0 | 5:5 | 4 |
| 4 | Salcburk | 4 | 0 | 2 | 2 | 1:5 | 2 |
Skupina B | |||||||
| 1 | Leverkusen | 4 | 2 | 2 | 0 | 6:1 | 8 |
| 2 | Atlético | 4 | 2 | 1 | 1 | 6:3 | 7 |
| 3 | Aris | 4 | 1 | 1 | 2 | 2:3 | 4 |
| 4 | Rosenborg | 4 | 1 | 0 | 3 | 3:10 | 3 |
Skupina C | |||||||
| 1 | Sporting | 4 | 3 | 0 | 1 | 13:5 | 9 |
| 2 | Lille | 4 | 1 | 2 | 1 | 5:5 | 5 |
| 3 | GENT | 4 | 1 | 1 | 2 | 7:10 | 4 |
| 4 | Levski | 4 | 1 | 1 | 2 | 5:10 | 4 |
Skupina D | |||||||
| 1 | Dinamo Záhřeb | 4 | 2 | 1 | 1 | 4:1 | 7 |
| 2 | PAOK Soluň | 4 | 2 | 1 | 1 | 3:2 | 7 |
| 3 | Villarreal | 4 | 2 | 0 | 2 | 3:4 | 6 |
| 4 | Bruggy | 4 | 0 | 2 | 2 | 2:5 | 2 |
Skupina E | |||||||
| 1 | BATE | 4 | 3 | 1 | 0 | 10:4 | 10 |
| 2 | Kyjev | 4 | 2 | 1 | 1 | 6:5 | 7 |
| 3 | Tiraspol | 4 | 1 | 0 | 3 | 4:6 | 3 |
| 4 | Alkmaar | 4 | 1 | 0 | 3 | 4:9 | 3 |
Skupina F | |||||||
| 1 | CSKA | 4 | 4 | 0 | 0 | 12:1 | 12 |
| 2 | Sparta | 4 | 2 | 1 | 1 | 9:9 | 7 |
| 3 | Palermo | 4 | 1 | 0 | 3 | 4:9 | 3 |
| 4 | Lausanne | 4 | 0 | 1 | 3 | 4:10 | 1 |
Skupina G | |||||||
| 1 | Zenit | 4 | 4 | 0 | 0 | 12:5 | 12 |
| 2 | Anderlecht | 4 | 1 | 1 | 2 | 5:5 | 4 |
| 3 | AEK | 4 | 1 | 1 | 2 | 6:9 | 4 |
| 4 | Hajduk Split | 4 | 1 | 0 | 3 | 4:8 | 3 |
Skupina H | |||||||
| 1 | Stuttgart | 4 | 4 | 0 | 0 | 9:1 | 12 |
| 2 | YB Bern | 4 | 2 | 0 | 2 | 6:7 | 6 |
| 3 | Odense | 4 | 1 | 0 | 3 | 6:8 | 3 |
| 4 | Getafe | 4 | 1 | 0 | 3 | 2:7 | 3 |
Skupina I | |||||||
| 1 | Eindhoven | 4 | 3 | 1 | 0 | 8:2 | 10 |
| 2 | Metalist | 4 | 2 | 1 | 1 | 7:3 | 7 |
| 3 | Sampdoria | 4 | 1 | 2 | 1 | 3:3 | 5 |
| 4 | Debrecín | 4 | 0 | 0 | 4 | 1:11 | 0 |
Skupina J | |||||||
| 1 | Sevilla | 4 | 3 | 0 | 1 | 6:1 | 9 |
| 2 | PSG | 4 | 2 | 2 | 0 | 4:1 | 8 |
| 3 | Dortmund | 4 | 1 | 2 | 1 | 5:5 | 5 |
| 4 | Karpaty | 4 | 0 | 0 | 4 | 3:11 | 0 |
Skupina K | |||||||
| 1 | Liverpool | 4 | 2 | 2 | 0 | 7:2 | 8 |
| 2 | Steaua | 4 | 1 | 2 | 1 | 8:9 | 5 |
| 3 | Neapol | 4 | 0 | 3 | 1 | 4:6 | 3 |
| 4 | Utrecht | 4 | 0 | 3 | 1 | 2:4 | 3 |
Skupina L | |||||||
| 1 | Porto | 4 | 3 | 1 | 0 | 8:2 | 10 |
| 2 | Besiktas | 4 | 2 | 1 | 1 | 5:5 | 7 |
| 3 | Rapid | 4 | 1 | 0 | 3 | 4:7 | 3 |
| 4 | Sofie | 4 | 1 | 0 | 3 | 2:5 | 3 |