Jediný záastupce z české ligy Sparta si zajistila na hřišti Palerma remízou 2:2 postup do vyřazovacích bojů. Letenský klub tak překonal sedmileté trápení, kdy v pohárové Evropě nepřežili do jarní části. Mezi dvaatřicítkou evropských klubů Sparta nebude pro další boje nasazená, a tak na Letnou může zavítat Liverpool či Manchester City.
výsledky - 5. kolo:
| Villarreal CF | - | Dinamo Záhřeb | 3:0 | 2. 12. 2010 | |
| PAOK Soluň | - | FC Bruggy | 1:1 | 2. 12. 2010 | |
| Šeriff Tiraspol | - | AZ Alkmaar | 1:1 | 2. 12. 2010 | |
| BATE Borisov | - | Dynamo Kyjev | 1:4 | 2. 12. 2010 | |
| Palermo | - | AC Sparta Praha | 2:2 | 2. 12. 2010 | |
| CSKA Moskva | - | FC Lausanne-Sport | 5:1 | 2. 12. 2010 | |
| Borussia Dortmund | - | FC Karpaty Lviv | 3:0 | 2. 12. 2010 | |
| Paris Saint-Germain | - | Sevilla FC | 4:2 | 2. 12. 2010 | |
| FC Utrecht | - | SSC Neapol | 3:3 | 2. 12. 2010 | |
| Steaua Bukurešť | - | FC Liverpool | 1:1 | 2. 12. 2010 | |
| CSKA Sofie | - | Besiktas | 1:2 | 2. 12. 2010 | |
| SK Rapid Vídeň | - | FC Porto | 1:3 | 2. 12. 2010 | |
| Manchester City FC | - | FC Red Bull Salcburk | 3:0 | 1. 12. 2010 | |
| Lech Poznaň | - | Juventus Turín | 1:1 | 1. 12. 2010 | |
| Atlético Madrid | - | Aris Soluň | 2:3 | 1. 12. 2010 | |
| Rosenborg Trondheim | - | Bayer 04 Leverkusen | 0:1 | 1. 12. 2010 | |
| Sporting Lisabon | - | LOSC Lille Metropole | 1:0 | 1. 12. 2010 | |
| K.A.A. Gent | - | PFC Levski Sofia | 1:0 | 1. 12. 2010 | |
| Zenit Petrohrad | - | Anderlecht Brusel | 3:1 | 1. 12. 2010 | |
| HNK Hajduk Split | - | AEK Atény | 1:3 | 1. 12. 2010 | |
| Young Boys Bern | - | VfB Stuttgart | 4:2 | 1. 12. 2010 | |
| Odense BK | - | Getafe CF | 1:1 | 1. 12. 2010 | |
| Metalist Charkov | - | Debrecín VSC | 2:1 | 1. 12. 2010 | |
| Sampdoria Janov | - | PSV Eindhoven | 1:2 | 1. 12. 2010 |
tabulky po 5. kole:
| Por. | Tým | Z | V | R | P | Skóre | B |
|---|---|---|---|---|---|---|---|
| Skupina A | |||||||
| 1 | Manchester City | 5 | 3 | 1 | 1 | 10:5 | 10 |
| 2 | Poznaň | 5 | 2 | 2 | 1 | 10:8 | 8 |
| 3 | Juventus | 5 | 0 | 5 | 0 | 6:6 | 5 |
| 4 | Salcburk | 5 | 0 | 2 | 3 | 1:8 | 2 |
| Skupina B | |||||||
| 1 | Leverkusen | 5 | 3 | 2 | 0 | 7:1 | 11 |
| 2 | Atlético | 5 | 2 | 1 | 2 | 8:6 | 7 |
| 3 | Aris | 5 | 2 | 1 | 2 | 5:5 | 7 |
| 4 | Rosenborg | 5 | 1 | 0 | 4 | 3:11 | 3 |
| Skupina C | |||||||
| 1 | Sporting | 5 | 4 | 0 | 1 | 14:5 | 12 |
| 2 | GENT | 5 | 2 | 1 | 2 | 8:10 | 7 |
| 3 | Lille | 5 | 1 | 2 | 2 | 5:6 | 5 |
| 4 | Levski | 5 | 1 | 1 | 3 | 5:11 | 4 |
| Skupina D | |||||||
| 1 | Villarreal | 5 | 3 | 0 | 2 | 6:4 | 9 |
| 2 | PAOK Soluň | 5 | 2 | 2 | 1 | 4:3 | 8 |
| 3 | Dinamo Záhřeb | 5 | 2 | 1 | 2 | 4:4 | 7 |
| 4 | Bruggy | 5 | 0 | 3 | 2 | 3:6 | 3 |
| Skupina E | |||||||
| 1 | Kyjev | 5 | 3 | 1 | 1 | 10:6 | 10 |
| 2 | BATE | 5 | 3 | 1 | 1 | 11:8 | 10 |
| 3 | Tiraspol | 5 | 1 | 1 | 3 | 5:7 | 4 |
| 4 | Alkmaar | 5 | 1 | 1 | 3 | 5:10 | 4 |
| Skupina F | |||||||
| 1 | CSKA | 5 | 5 | 0 | 0 | 17:2 | 15 |
| 2 | Sparta | 5 | 2 | 2 | 1 | 11:11 | 8 |
| 3 | Palermo | 5 | 1 | 1 | 3 | 6:11 | 4 |
| 4 | Lausanne | 5 | 0 | 1 | 4 | 5:15 | 1 |
| Skupina G | |||||||
| 1 | Zenit | 5 | 5 | 0 | 0 | 15:6 | 15 |
| 2 | AEK | 5 | 2 | 1 | 2 | 9:10 | 7 |
| 3 | Anderlecht | 5 | 1 | 1 | 3 | 6:8 | 4 |
| 4 | Hajduk Split | 5 | 1 | 0 | 4 | 5:11 | 3 |
| Skupina H | |||||||
| 1 | Stuttgart | 5 | 4 | 0 | 1 | 11:5 | 12 |
| 2 | YB Bern | 5 | 3 | 0 | 2 | 10:9 | 9 |
| 3 | Odense | 5 | 1 | 1 | 3 | 7:9 | 4 |
| 4 | Getafe | 5 | 1 | 1 | 3 | 3:8 | 4 |
| Skupina I | |||||||
| 1 | Eindhoven | 5 | 4 | 1 | 0 | 10:3 | 13 |
| 2 | Metalist | 5 | 3 | 1 | 1 | 9:4 | 10 |
| 3 | Sampdoria | 5 | 1 | 2 | 2 | 4:5 | 5 |
| 4 | Debrecín | 5 | 0 | 0 | 5 | 2:13 | 0 |
| Skupina J | |||||||
| 1 | PSG | 5 | 3 | 2 | 0 | 8:3 | 11 |
| 2 | Sevilla | 5 | 3 | 0 | 2 | 8:5 | 9 |
| 3 | Dortmund | 5 | 2 | 2 | 1 | 8:5 | 8 |
| 4 | Karpaty | 5 | 0 | 0 | 5 | 3:14 | 0 |
| Skupina K | |||||||
| 1 | Liverpool | 5 | 2 | 3 | 0 | 8:3 | 9 |
| 2 | Steaua | 5 | 1 | 3 | 1 | 9:10 | 6 |
| 3 | Neapol | 5 | 0 | 4 | 1 | 7:9 | 4 |
| 4 | Utrecht | 5 | 0 | 4 | 1 | 5:7 | 4 |
| Skupina L | |||||||
| 1 | Porto | 5 | 4 | 1 | 0 | 11:3 | 13 |
| 2 | Besiktas | 5 | 3 | 1 | 1 | 7:6 | 10 |
| 3 | Sofie | 5 | 1 | 0 | 4 | 3:7 | 3 |
| 4 | Rapid | 5 | 1 | 0 | 4 | 5:10 | 3 |