Mezi 16 postupujících do osmifinálových bojů patří: Tottenham, Inter Milan, Schalke04, Lyon, Manchester United, Valencia, Barcelona, Kodaň, Bayern Mnicov, AS Řím, Chelsea, Marseille, Real Madrid, AC Milan, Šachtar Doněck, Arsenal
výsledky 6. kol základních skupin:
| Bayern Mnichov | - | FC Basilej | 3:0 | 8. 12. 2010 | |
| CFR Kluž | - | AS Řím | 1:1 | 8. 12. 2010 | |
| Olympique Marseille | - | Chelsea FC | 1:0 | 8. 12. 2010 | |
| MŠK Žilina | - | Spartak Moskva | 1:2 | 8. 12. 2010 | |
| Real Madrid C.F. | - | AJ Auxerre | 4:0 | 8. 12. 2010 | |
| AC Milán | - | Ajax Amsterdam | 0:2 | 8. 12. 2010 | |
| Arsenal F.C. | - | Partizan Bělehrad | 3:1 | 8. 12. 2010 | |
| FK Šachtar Doněck | - | Sporting Braga | 2:0 | 8. 12. 2010 | |
| Twente Enschede | - | Tottenham Hotspur FC | 3:3 | 7. 12. 2010 | |
| SV Werder Brémy | - | Inter Milán | 3:0 | 7. 12. 2010 | |
| Olympique Lyon | - | Hapoel Tel Aviv | 2:2 | 7. 12. 2010 | |
| Benfica Lisabon FC | - | Schalke 04 | 1:2 | 7. 12. 2010 | |
| Manchester United | - | Valencia CF | 1:1 | 7. 12. 2010 | |
| Bursaspor | - | Glasgow Rangers FC | 1:1 | 7. 12. 2010 | |
| FC Barcelona | - | FC Rubin Kazaň | 2:0 | 7. 12. 2010 | |
| FC Kodaň | - | Panathinaikos Atény | 3:1 | 7. 12. 2010 |
tabulky:
| Por. | Tým | Z | V | R | P | Skóre | B |
|---|---|---|---|---|---|---|---|
| Skupina A | |||||||
| 1 | Tottenham | 6 | 3 | 2 | 1 | 18:11 | 11 |
| 2 | Inter | 6 | 3 | 1 | 2 | 12:11 | 10 |
| 3 | Twente | 6 | 1 | 3 | 2 | 9:11 | 6 |
| 4 | Brémy | 6 | 1 | 2 | 3 | 6:12 | 5 |
| Skupina B | |||||||
| 1 | Schalke | 6 | 4 | 1 | 1 | 10:3 | 13 |
| 2 | Lyon | 6 | 3 | 1 | 2 | 11:10 | 10 |
| 3 | Benfica | 6 | 2 | 0 | 4 | 7:12 | 6 |
| 4 | Hapoel | 6 | 1 | 2 | 3 | 7:10 | 5 |
| Skupina C | |||||||
| 1 | Manchester Utd. | 6 | 4 | 2 | 0 | 7:1 | 14 |
| 2 | Valencia | 6 | 3 | 2 | 1 | 15:4 | 11 |
| 3 | Rangers | 6 | 1 | 3 | 2 | 3:6 | 6 |
| 4 | Bursaspor | 6 | 0 | 1 | 5 | 2:16 | 1 |
| Skupina D | |||||||
| 1 | Barcelona | 6 | 4 | 2 | 0 | 14:3 | 14 |
| 2 | Kodaň | 6 | 3 | 1 | 2 | 7:5 | 10 |
| 3 | Kazaň | 6 | 1 | 3 | 2 | 2:4 | 6 |
| 4 | Panathinaikos | 6 | 0 | 2 | 4 | 2:13 | 2 |
| Skupina E | |||||||
| 1 | Bayern | 6 | 5 | 0 | 1 | 16:6 | 15 |
| 2 | AS Řím | 6 | 3 | 1 | 2 | 10:11 | 10 |
| 3 | Basilej | 6 | 2 | 0 | 4 | 8:11 | 6 |
| 4 | Kluž | 6 | 1 | 1 | 4 | 6:12 | 4 |
| Skupina F | |||||||
| 1 | Chelsea | 6 | 5 | 0 | 1 | 14:4 | 15 |
| 2 | Marseille | 6 | 4 | 0 | 2 | 12:3 | 12 |
| 3 | Spartak | 6 | 3 | 0 | 3 | 7:10 | 9 |
| 4 | Žilina | 6 | 0 | 0 | 6 | 3:19 | 0 |
| Skupina G | |||||||
| 1 | Real Madrid | 6 | 5 | 1 | 0 | 15:2 | 16 |
| 2 | AC Milán | 6 | 2 | 2 | 2 | 7:7 | 8 |
| 3 | Ajax | 6 | 2 | 1 | 3 | 6:10 | 7 |
| 4 | Auxerre | 6 | 1 | 0 | 5 | 3:12 | 3 |
| Skupina H | |||||||
| 1 | Šachtar | 6 | 5 | 0 | 1 | 12:6 | 15 |
| 2 | Arsenal | 6 | 4 | 0 | 2 | 18:7 | 12 |
| 3 | Braga | 6 | 3 | 0 | 3 | 5:11 | 9 |
| 4 | Partizan | 6 | 0 | 0 | 6 | 2:13 | 0 |