Wolverhampton - Chelsea 1:0
Manchester United - Stoke City 2:1
Arsenal - Manchester City 0:0
Everton - Tottenham 2:1
Newcastle United - West Ham United 5:0
Fulham - West Bromwich Albion 3:0
Blackpool - Birmingham 1:2
Aston Villa - Sunderland 0:1
Blackburn - Liverpool 3:1
Bolton - Wigan 1:1
Ve 22. kole Premier League celkem padlo 25 branek, průměrně na zápas 2,5 gólů
tabulka po 22. kole:
| Por. | Tým | Z | V | R | P | Skóre | B |
|---|---|---|---|---|---|---|---|
| 1 | Manchester Utd. | 20 | 12 | 8 | 0 | 43:19 | 44 |
| 2 | Manchester City | 22 | 12 | 6 | 4 | 33:16 | 42 |
| 3 | Arsenal | 21 | 12 | 4 | 5 | 42:22 | 40 |
| 4 | Tottenham | 21 | 10 | 6 | 5 | 31:25 | 36 |
| 5 | Chelsea | 21 | 10 | 5 | 6 | 36:19 | 35 |
| 6 | Sunderland | 22 | 8 | 9 | 5 | 25:22 | 33 |
| 7 | Bolton | 22 | 7 | 9 | 6 | 34:29 | 30 |
| 8 | Newcastle | 21 | 8 | 4 | 9 | 34:31 | 28 |
| 9 | Blackburn | 22 | 8 | 4 | 10 | 29:35 | 28 |
| 10 | Stoke | 21 | 8 | 3 | 10 | 26:26 | 27 |
| 11 | Everton | 21 | 5 | 10 | 6 | 23:25 | 25 |
| 12 | Liverpool | 20 | 7 | 4 | 9 | 24:27 | 25 |
| 13 | Blackpool | 19 | 7 | 4 | 8 | 27:32 | 25 |
| 14 | Fulham | 21 | 4 | 10 | 7 | 22:24 | 22 |
| 15 | Birm'ham | 20 | 4 | 10 | 6 | 20:25 | 22 |
| 16 | West Bromwich | 21 | 6 | 4 | 11 | 26:39 | 22 |
| 17 | Wolves | 21 | 6 | 3 | 12 | 21:34 | 21 |
| 18 | Aston Villa | 21 | 5 | 6 | 10 | 23:38 | 21 |
| 19 | Wigan | 21 | 4 | 9 | 8 | 18:33 | 21 |
| 20 | West Ham | 22 | 4 | 8 | 10 | 22:38 | 20 |
následující kolo:
| Birmingham City FC | - | FC Aston Villa | 16. 1. 2011 |
| Sunderland AFC | - | Newcastle United FC | 16. 1. 2011 |
| Chelsea FC | - | Blackburn Rovers FC | 15. 1. 2011 |
| FC Liverpool | - | Everton FC | 15. 1. 2011 |
| Manchester City FC | - | Wolverhampton Wanderers | 15. 1. 2011 |
| Stoke City | - | Bolton Wanderers FC | 15. 1. 2011 |
| Tottenham Hotspur FC | - | Manchester United | 15. 1. 2011 |
| West Bromwich Albion | - | Blackpool FC | 15. 1. 2011 |
| West Ham United | - | Arsenal F.C. | 15. 1. 2011 |
| Wigan Athletics FC | - | Fulham FC | 15. 1. 2011 |
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