BATE Borisov - Plzeň 0:1
Leverkusen - Chelsea 2:1
Manchester United - Benfika Lisabon 2:2
Real Madrid - Dinamo Záhřeb 6:2
Valencie - Genk 7:0
AC Milan - Barcelona 2:3
Trabzonspor - Inter Milan 1:1
Neapol - Manchester City 2:1
Galati Otelul - Basilej 2:3
Bayern Mnichov - Villareal 3:1
Arsenal - Dortmund 2:1
Zenit Petrohrad - Apoel 0:0
CSKA Moskva - Lille 0:2
Šachtar Doněck - Porto 0:2
Olympique Marseille - Olympique Pireus 0:1
Olympique Lyon - Ajax Armsterdam 0:0
jistí postupující: Bayern Mnichov, Inter Milan, Arsenal, Barcelona, Real Madrid, AC Milan
Tabulky po 5. kole:
| Por. | Tým | Z | V | R | P | Skóre | B |
|---|---|---|---|---|---|---|---|
| Skupina A | |||||||
| 1 | Bayern | 5 | 4 | 1 | 0 | 11:4 | 13 |
| 2 | Neapol | 5 | 2 | 2 | 1 | 8:6 | 8 |
| 3 | Manchester City | 5 | 2 | 1 | 2 | 7:6 | 7 |
| 4 | Villarreal | 5 | 0 | 0 | 5 | 2:12 | 0 |
| Skupina B | |||||||
| 1 | Inter | 5 | 3 | 1 | 1 | 7:5 | 10 |
| 2 | Trabzonspor | 5 | 1 | 3 | 1 | 3:5 | 6 |
| 3 | CSKA | 5 | 1 | 2 | 2 | 7:7 | 5 |
| 4 | Lille | 5 | 1 | 2 | 2 | 6:6 | 5 |
| Skupina C | |||||||
| 1 | Manchester Utd. | 5 | 2 | 3 | 0 | 10:6 | 9 |
| 2 | Benfica | 5 | 2 | 3 | 0 | 7:4 | 9 |
| 3 | Basilej | 5 | 2 | 2 | 1 | 9:9 | 8 |
| 4 | Galati | 5 | 0 | 0 | 5 | 3:10 | 0 |
| Skupina D | |||||||
| 1 | Real Madrid | 5 | 5 | 0 | 0 | 16:2 | 15 |
| 2 | Ajax | 5 | 2 | 2 | 1 | 6:3 | 8 |
| 3 | Lyon | 5 | 1 | 2 | 2 | 2:6 | 5 |
| 4 | Dinamo Záhřeb | 5 | 0 | 0 | 5 | 2:15 | 0 |
| Skupina E | |||||||
| 1 | Leverkusen | 5 | 3 | 0 | 2 | 7:7 | 9 |
| 2 | Valencia | 5 | 2 | 2 | 1 | 12:4 | 8 |
| 3 | Chelsea | 5 | 2 | 2 | 1 | 10:4 | 8 |
| 4 | Genk | 5 | 0 | 2 | 3 | 1:15 | 2 |
| Skupina F | |||||||
| 1 | Arsenal | 5 | 3 | 2 | 0 | 6:3 | 11 |
| 2 | Marseille | 5 | 2 | 1 | 2 | 4:2 | 7 |
| 3 | Olympiakos | 5 | 2 | 0 | 3 | 5:5 | 6 |
| 4 | Dortmund | 5 | 1 | 1 | 3 | 4:9 | 4 |
| Skupina G | |||||||
| 1 | APOEL | 5 | 2 | 3 | 0 | 6:4 | 9 |
| 2 | Zenit | 5 | 2 | 2 | 1 | 7:5 | 8 |
| 3 | Porto | 5 | 2 | 1 | 2 | 7:7 | 7 |
| 4 | Šachtar | 5 | 0 | 2 | 3 | 4:8 | 2 |
| Skupina H | |||||||
| 1 | Barcelona | 5 | 4 | 1 | 0 | 16:4 | 13 |
| 2 | AC Milán | 5 | 2 | 2 | 1 | 9:6 | 8 |
| 3 | Plzeň | 5 | 1 | 1 | 3 | 2:9 | 4 |
| 4 | BATE | 5 | 0 | 2 | 3 | 2:10 | 2 |
následující kolo:
| 6. kolo | |||
|---|---|---|---|
| Manchester City FC | - | Bayern Mnichov | 7. 12. 2011 |
| Villarreal CF | - | SSC Neapol | 7. 12. 2011 |
| LOSC Lille Metropole | - | Trabzonspor | 7. 12. 2011 |
| Inter Milán | - | CSKA Moskva | 7. 12. 2011 |
| FC Basilej | - | Manchester United | 7. 12. 2011 |
| Benfica Lisabon FC | - | FC Otelul Galati | 7. 12. 2011 |
| Dinamo Záhřeb | - | Olympique Lyon | 7. 12. 2011 |
| Ajax Amsterdam | - | Real Madrid C.F. | 7. 12. 2011 |
| Chelsea FC | - | Valencia CF | 6. 12. 2011 |
| Racing Genk | - | Bayer 04 Leverkusen | 6. 12. 2011 |
| Olympiakos Pireus | - | Arsenal F.C. | 6. 12. 2011 |
| Borussia Dortmund | - | Olympique Marseille | 6. 12. 2011 |
| FC Porto | - | Zenit Petrohrad | 6. 12. 2011 |
| APOEL FC | - | FK Šachtar Doněck | 6. 12. 2011 |
| FC Barcelona | - | BATE Borisov | 6. 12. 2011 |
| FC Viktoria Plzeň | - | AC Milán | 6. 12. 2011 |